Description / Application
Trioxsalen is 7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis. It has a role as a photosensitizing agent and a dermatologic drug.
Identities
| Alternative Name | 2,5,9-Trimethylfuro[3,2-g]benzopyran-7-one; 4,5',8-Trimethylpsoralen; TMP; Trisoralen |
|---|---|
| Molecular Formula | C14H12O3 |
| Molecular Weight | 228.24 |
| MFCD | MFCD00005010 |
Transport
| DOT UN Number | UN1759 |
|---|---|
| Hazard Class | 8 |
| Packing Group | II |
Safety
| Pictograms |
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|---|---|
| Signal Word | Danger |
| Hazard Statements | H314;H351 |
| Precautionary Statements | P201;P202;P260;P264;P280;P301+P330+P331;P303+P361+P353;P304+P340;P305+P351+P338;P310;P321;P363;P405;P501 |