Description / Application
GI254023X is a L-valine derivative that is 3-methyl-L-valine in which carboxy OH group is replaced by a methylnitrilo group and the one of the amino hydrogens is replaced by a (2R)-2-{(1S)-1-[formyl(hydroxy)amino]ethyl}-5-phenylpentanoyl group. It is a potent MMP9 and ADAM10 metalloprotease inhibitor with IC50 of 2.5 and 5.3 nM, respectively. It has a role as an antineoplastic agent, a matrix metalloproteinase inhibitor, an EC 3.4.24.* (metalloendopeptidase) inhibitor and an apoptosis inducer. It is an aldehyde, a member of hydroxylamines and a L-valine derivative.
Identities
| Alternative Name | (2R)-N-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]-propyl]-2-[(1S)-1-[formyl(hydroxy)amino]ethyl]-5-phenylpentanamide |
|---|---|
| Molecular Formula | C21H33N3O4 |
| Molecular Weight | 391.5 |
| MFCD | MFCD19381832 |
Safety
| Pictograms |
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|---|---|
| Signal Word | Warning |
| Hazard Statements | H315;H319;H335 |
| Precautionary Statements | P261;P264;P271;P280;P302+P352;P304+P340;P305+P351+P338;P312;P321;P332+P313;P337+P313;P362;P403+P233;P405;P501 |