Aphidicolin is a tetracyclic diterpenoid that has an tetradecahydro-8,11a-methanocyclohepta[a]naphthalene skeleton with two hydroxymethyl substituents at positions 4 and 9, two methyl substituents at positions 4 and 11b and two hydroxy substituents at positions 3 and 9. An antibiotic with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication. It has a role as an EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor, an antimicrobial agent, an antineoplastic agent, an antiviral drug, a DNA synthesis inhibitor, an antimitotic, an apoptosis inducer, a fungal metabolite and an Aspergillus metabolite.
